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Isao Hara Selected Research

Clusterin

9/2006Expression of clusterin in prostate cancer correlates with Gleason score but not with prognosis in patients undergoing radical prostatectomy without neoadjuvant hormonal therapy.
5/2006The potential of clusterin inhibiting antisense oligodeoxynucleotide therapy for prostate cancer.
11/2005Enhanced expression of the secreted form of clusterin following neoadjuvant hormonal therapy as a prognostic predictor in patients undergoing radical prostatectomy for prostate cancer.
10/2005Expression of the secreted form of clusterin protein in renal cell carcinoma as a predictor of disease extension.
9/2005Antisense oligodeoxynucleotide therapy targeting clusterin gene for prostate cancer: Vancouver experience from discovery to clinic.
5/2005Enhanced radiosensitivity by inhibition of the anti-apoptotic gene clusterin using antisense oligodeoxynucleotide in a human bladder cancer model.
2/2005Synergistic antitumor effect of combined use of adenoviral-mediated p53 gene transfer and antisense oligodeoxynucleotide targeting clusterin gene in an androgen-independent human prostate cancer model.
2/2005Therapeutic efficacy of adenoviral-mediated p53 gene transfer is synergistically enhanced by combined use of antisense oligodeoxynucleotide targeting clusterin gene in a human bladder cancer model.
12/2004Protection of androgen-dependent human prostate cancer cells from oxidative stress-induced DNA damage by overexpression of clusterin and its modulation by androgen.
6/2004Synergistic antitumor activity by combined treatment with gemcitabine and antisense oligodeoxynucleotide targeting clusterin gene in an intravesical administration model against human bladder cancer kotcc-1 cells.
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Isao Hara Research Topics

Disease

103Neoplasms (Cancer)
07/2021 - 01/2002
76Prostatic Neoplasms (Prostate Cancer)
01/2022 - 04/2002
34Urinary Bladder Neoplasms (Bladder Cancer)
01/2022 - 01/2002
30Neoplasm Metastasis (Metastasis)
01/2020 - 05/2002
15Lymphatic Metastasis
06/2018 - 10/2004
14Renal Cell Carcinoma (Grawitz Tumor)
01/2021 - 02/2002
12Carcinoma (Carcinomatosis)
02/2017 - 10/2003
11Disease Progression
01/2022 - 01/2002
11Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)
12/2007 - 03/2002
10Testicular Neoplasms (Testicular Cancer)
06/2018 - 03/2002
7Shock
12/2020 - 06/2007
7Transitional Cell Carcinoma
11/2006 - 01/2002
6Urinary Calculi (Urinary Calculus)
01/2018 - 01/2008
5Urologic Neoplasms (Urological Cancer)
11/2017 - 06/2007
5Carcinoma in Situ
04/2008 - 12/2002
4Urinary Incontinence
01/2022 - 03/2005
4Inflammation (Inflammations)
11/2021 - 12/2005
4Margins of Excision
01/2021 - 01/2006
4Kidney Calculi (Kidney Stone)
12/2020 - 12/2010
4Melanoma (Melanoma, Malignant)
06/2006 - 09/2002
3Necrosis
01/2020 - 09/2002
3Non-Muscle Invasive Bladder Neoplasms
09/2018 - 08/2010
3Pelvic Neoplasms
02/2017 - 05/2014
3Metabolic Syndrome (Dysmetabolic Syndrome X)
06/2013 - 11/2010
3Thrombosis (Thrombus)
09/2007 - 02/2006
3Neoplasm Micrometastasis
02/2007 - 05/2005
3Male Germ Cell Tumor
10/2006 - 12/2005
3Nonseminomatous germ cell tumor
09/2005 - 09/2004
3Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
07/2004 - 11/2002
2Sarcopenia
01/2022 - 07/2021
2Respiratory Insufficiency (Respiratory Failure)
09/2021 - 11/2010
2Infections
01/2021 - 07/2009
2Hydronephrosis
01/2021 - 01/2006
2Urolithiasis
01/2021 - 01/2011

Drug/Important Bio-Agent (IBA)

19Prostate-Specific Antigen (Semenogelase)IBA
04/2017 - 06/2002
15Cisplatin (Platino)FDA LinkGeneric
01/2017 - 09/2003
15AndrogensIBA
01/2016 - 06/2002
14ClusterinIBA
09/2006 - 01/2002
11Hormones (Hormone)IBA
07/2018 - 02/2005
8Biomarkers (Surrogate Marker)IBA
11/2021 - 10/2003
8Docetaxel (Taxotere)FDA Link
09/2021 - 03/2005
8AntigensIBA
01/2020 - 01/2004
8GemcitabineFDA Link
01/2017 - 06/2004
7Indocyanine Green (Cardio-Green)FDA LinkGeneric
06/2019 - 01/2012
7OligodeoxyribonucleotidesIBA
05/2006 - 06/2004
6Therapeutic UsesIBA
01/2020 - 09/2005
6MicellesIBA
01/2018 - 03/2012
6Proteins (Proteins, Gene)FDA Link
01/2017 - 11/2003
6Biological ProductsIBA
09/2007 - 06/2004
5Heat-Shock Proteins (Heat-Shock Protein)IBA
03/2018 - 01/2004
5OsteocalcinIBA
05/2009 - 11/2002
5Etoposide (VP 16)FDA LinkGeneric
12/2007 - 12/2005
5RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
02/2007 - 03/2002
5Messenger RNA (mRNA)IBA
02/2007 - 01/2002
4Pharmaceutical PreparationsIBA
06/2019 - 07/2006
41-phenyl-3,3-dimethyltriazene (PDT)IBA
06/2019 - 12/2013
4Peptides (Polypeptides)IBA
09/2018 - 02/2005
4Tumor Biomarkers (Tumor Markers)IBA
06/2018 - 10/2003
4Zoledronic Acid (Zometa)FDA Link
01/2016 - 01/2014
4Calcium OxalateIBA
04/2015 - 12/2010
4Uric Acid (Urate)IBA
04/2015 - 11/2010
4poly(lactide) (polylactic acid)IBA
08/2013 - 10/2009
3CytokinesIBA
10/2020 - 10/2004
3OxalatesIBA
01/2020 - 01/2011
3Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric
06/2018 - 03/2002
3InterferonsIBA
01/2018 - 09/2002
3Antineoplastic Agents (Antineoplastics)IBA
01/2017 - 09/2005
3Citric Acid (Citrate)FDA LinkGeneric
04/2015 - 11/2010
3Monoclonal AntibodiesIBA
08/2014 - 01/2004
3CalciumIBA
06/2013 - 11/2010
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2009 - 09/2005
3Thymidine KinaseIBA
05/2009 - 06/2006
3Granulocyte Colony-Stimulating Factor (G-CSF)IBA
02/2009 - 05/2005
3Bleomycin (Blenoxane)FDA LinkGeneric
12/2007 - 10/2006
3Carboplatin (JM8)FDA LinkGeneric
01/2007 - 12/2005
3IfosfamideFDA LinkGeneric
01/2007 - 12/2005
3O-(Chloroacetylcarbamoyl)fumagillol (TNP 470)IBA
03/2005 - 11/2003
2Insulin (Novolin)FDA Link
01/2022 - 11/2010

Therapy/Procedure

64Therapeutics
09/2021 - 06/2002
40Prostatectomy (Retropubic Prostatectomy)
12/2022 - 04/2002
29Drug Therapy (Chemotherapy)
09/2021 - 03/2003
17Cystectomy
01/2022 - 01/2002
14Nephrectomy
01/2021 - 02/2002
13Lymph Node Excision (Lymph Node Dissection)
06/2018 - 03/2004
12Radiotherapy
07/2021 - 06/2002
11Immunotherapy
09/2018 - 01/2004
8Castration
09/2021 - 06/2002
7Brachytherapy
07/2021 - 02/2006
7Lithotripsy (Extracorporeal Shockwave Lithotripsy)
12/2020 - 06/2007
7Nephroureterectomy
02/2017 - 09/2006
7Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation)
04/2007 - 07/2004
6Combination Drug Therapy (Combination Chemotherapy)
01/2017 - 09/2003
5Neoadjuvant Therapy
01/2007 - 07/2003
3Stents
01/2021 - 01/2006
3Photochemotherapy (Photodynamic Therapy)
01/2017 - 12/2013
3Transplantation
01/2015 - 03/2002
3Intravesical Administration
11/2006 - 01/2003
3Adrenalectomy
12/2005 - 08/2004
2Aftercare (After-Treatment)
04/2021 - 01/2018
2Punctures
01/2021 - 01/2013